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Demographic characteristics and the stage of dementia were similar in the two groups ( Table 1 Baseline Characteristics at Randomization According to Study Group.
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In patient 2, significant conduction system disease with right bundle branch block and left anterior hemiblock associated with the duration of the arrest suggested infra-His disease as the primary problem rather than a drug effect which would be expected at the AV nodal level.
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Rockville, MD: Agency for Healthcare Research and Quality; April 2004.
An 87-year-old woman with Alzheimer's disease was admitted because of syncope and persistent sinus bradycardia at 45 bpm.
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Most rapid cognitive decline in APOE ε4 negative Alzheimer's disease with early onset.
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Baseline characteristics among the three groups were compared with the use of Wilcoxon's rank-sum test or Fisher's exact test, as appropriate.
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Funding: The recommended budget was not met; the funding allocated to projects specific to this objective falls far short of the recommendation.
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Atropine (1 mg) was administered to patient 1 during electrophysiological study without any significant change in measured data.
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Alzheimer's disease is characterized by cholinergic deficiency in the cortex and basal forebrain, which contributes to cognitive deficits.
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Daily function was assessed using the Modified Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory for Severe Alzheimer's Disease (ADCS-ADL-severe).
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On verification by a central review committee that a participant met these clinical criteria for Alzheimer's disease, the participant stopped taking donepezil or matching placebo in a blinded fashion and was offered open-label donepezil until he or she completed the study at month 36.
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After multiple dose administration of memantine hydrochloride extended-release, memantine peak concentrations occur around 9-12 hours postdose.
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Concurrent administration of donepezil HC1 and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses.
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Using a matrix-analytical approach to synthesizing evidence solved incompatibility problem in the hierarchy of evidence.
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